Eight of the twenty four nations that featured at the 2019 Total Africa Cup of Nations in Egypt have missed chance to qualify for the 2021 edition.
Former champions South Africa lead the cast of nations that will watch proceedings in Cameroon on television.
The 1996 winners lost 2-0 to Sudan in the last match to miss out at the expense of the Falcons of Jeddah who will play at the finals for the first time since 2012.
In Egypt 2019, the Bafana Bafana reached the quarter finals only to be ousted by Nigeria after shockingly sending out hosts Egypt at the round of 16.
Other teams that miss out include Uganda whose place has been taken by Malawi; qualifying for the first time in more than a decade.
Uganda, just like South Africa needed to avoid defeat at the hands of Malawi on the final day of the qualifiers but lost 1-0 thanks to Richard Mbulu’s header.
The East African quarter of Kenya, Tanzania, Burundi and Rwanda also failed to qualify for Cameroon 2021 and are joined by perennial contenders DR Congo as well as lowly ranked Madagascar and Namibia.
With the tie between Benin and Sierra Leone to be played in June, a ninth team that played in Egypt could miss out if the former lose by at least 2-0 to the latter.
Benin are on seven points, three ahead of Sierra Leone who beat them 1-0 in the reverse fixture.
2021 Qualified Teams: Algeria, Burkina Faso, Cameroon, Cape Verde, Comoros, Cote d’Ivoire, Egypt, Ethiopia, Equatorial Guinea, Gabon, Ghana, Gambia, Guinea, Guinea Bissau, Malawi, Mali, Mauritania, Morocco, Nigeria, Senegal, Sudan, Tunisia, Zimbabwe.
To be decided: Benin or Sierra Leone
2019 Qualified Teams: Algeria, Angola, Burundi, Cameroon, Cote d’Ivoire, Egypt, Ghana, Guinea, Guinea Bissau, Mali, Madagascar, Morocco, Nigeria, Senegal, Uganda, Mauritania, Kenya, Tunisia, Zimbabwe, Namibia, DR Congo, *Benin*, Tanzania and South Africa.