| Rank | Player | Team | Goals |
|---|---|---|---|
| 1 |  Caesar Manzoki |  | 11 |
| 2 |  Steven Mukwala |  | 11 |
| 3 | Yunus Sentamu | | 10 |
| 4 | Mohammad Shaban |  | 8 |
| 5 | Musa Esenu |  | 8 |
| 6 | Ibra Nsimbe | | 8 |
| 7 | Viane Sekajugo | | 7 |
| 8 | Cromwel Rwotomiyo | | 7 |
| 9 | Alfred Leku |  | 7 |
| 10 | Juma Balinya |  | 7 |
2021/22 Uganda Premier League Top Scorers